Recently a new with title "End of fillings on horizon" showed up on 9news. It actually came from a study at King’s College London. The study showed that low doses of small molecule glycogen synthase kinase (GSK-3) inhibitors (Tideglusib, a drug that has already been tested in clinical trials for Alzheimer’s disease. ) can stimulate the stem cells contained in the pulp of the tooth and generate new dentine – the mineralised material that protects the tooth - in large cavities.
There is no doubt that it could be very promising in the future. But how about enamel? We all know how sensitive the exposed dentine is, so the new dentine still needs a filling to cover it.
In this study, all different materials were tried on a injured, non-contaminated exposed pulp (the nerve inside a tooth). But in reality, all decays are caused by bacterial and it can't be a non-contaminated environment. When the decay needs to be drilled to the pulp, that means the bacterial has already reached the pulp. How will infected and inflamed pulp react to Tideglusib?
It's definitely a good news in dentistry but we still can't clearly see end of fillings on the horizon.
The research was published in the journal Scientific Reports.